Friday, February 28, 2014

Girls Toys, Boy Toys: Gendered Preference for Childhood Playthings

In her book “Pink Brain, Blue Brain,” Lise Eliot discusses the differences in behavior and aptitude between boys and girls, and how these differences have been explained, both correctly and incorrectly, by neuroscience. In a section entitled “Toddlers and Their Toys” Eliot brings up “boy toys,” “girl toys,” and the early gender bias in choosing playthings, which she cites as one of the largest and most obvious early psychological differences. By the age of 12 months there is said to be a significant difference in toy choices between boys and girls. However, the effect weakens with age, especially for girls, and it is doubtful how important these choices are to development over time despite the early strength of the bias.

A commonly studied toy dichotomy is the difference in preference for either dolls or toy trucks. Most studies show a similar pattern: at six-months children tend to favor the two toys at least equally, with the dolls usually winning out, especially for girls. By the age of 12 months, girls favor dolls and boys favor trucks. By the age of 5 boys spend drastically favor trucks, but girls once again divide their attention almost equally between the gendered toys. Many attribute this tendency to our society’s more rigid demands for men to fit into traditional gender roles and the growing acceptability for women to take on more traditionally masculine roles. In short, they say that we give girls more freedom to choose, to split their attention equally.  In any case, this view suggests that toy choices are not innate, nor are they predictive of a child’s disposition and choices later in life.

Others suggest that toy choice is indeed innate. Evidence for this viewpoint comes in the form of monkey research. In studies using vervet and rhesus monkeys it was shown that female monkeys spent more time playing with rag dolls and red cooking pots, males spend more time with balls and toy cars, and that both sexes spent equal time with gender neutral toys such as a stuffed dog or a book. Because monkeys are not human, and thus have not been socially conditioned to recognize toys, much less if a certain toy is for boys or girls, the results suggest that toy preferences may have an innate factor. According to this school of thought girls are innately drawn to babies (the red pot preferred by female vervets was the same color as a baby vervet’s face) and boys are drawn to action and motion, such as that of a ball or a car. After discussing both possibilities, Eliot proceeds with the understanding that toy preference across genders is probably a result of both innate and social factors, a wise and highly probable conclusion.

Given these findings, one might ask “How should we go about gendering and marketing toys?” A New York Times article by Peggy Orenstein does just that. In “Should the World of Toys be Gender-Free?” Orenstein discusses the differences in gendered toy choices and recent moves by toymakers and sellers in both more and less-gendered directions. On one side we have F.A.O. Schwartz, a London based department store that rearranged its entire toy sales floor to be gender neutral. It donned red and white décor, instead of the traditional blue and pink, and arranged toys by interest instead of gender categories. On the other end of the spectrum in Lego, who unveiled a new collection of Lego products aimed at girls, featuring pastel colored blocks and more girlish figurines. The article explores both sides of the issue, citing some of the same research used by Eliot. Both sides argue for gender-fairness which they see manifesting itself in different ways. To some it is brought about by reaping the benefits that come with a variety of gender-neutral play styles, to others it means access to gendered toys that a male or female child is more disposed to desire.



This leaves us asking, which way is the right way? I think the better question is “Is there really a right way at all?” The fact remains that kids will choose the toys that they choose. Most girls will choose dolls and most boys will choose trucks, others will go against the grain. While childhood is a very important period of development, toy choice has not been shown to be highly predictive of future behavior or performance. As long as a child is developing healthily and happily, gendered toy choices are very interesting but do not appear to be highly influential. I would sooner devote more research to WHY gender preferences exist than whether they SHOULD exist. 

Article: http://www.nytimes.com/2011/12/30/opinion/does-stripping-gender-from-toys-really-make-sense.html?action=click&module=Search&region=searchResults%230&version=&url=http%3A%2F%2Fquery.nytimes.com%2Fsearch%2Fsitesearch%2F%3Faction%3Dclick%26region%3DMasthead%26pgtype%3DSectionFront%26module%3DSearchSubmit%26contentCollection%3Dscience%26t%3Dqry187%23%2Fgender+differences

Friday, December 13, 2013

Binging Babies



It is hard to deny that United States culture is heavily influenced by consumption of controlled substances, especially alcohol. This influence becomes particularly concerning when it involves youth. But I am not going to get into the obvious effects of media on alcohol consumption and the negative effects alcohol consumption has on society at large. While these are important topics to be discussed, I would like to highlight some neurobiological studies showing the dysregulation of hormones and increase of neuroimmune danger signals caused by high levels of alcohol consumption. Understanding the extent of drinking, especially binge drinking (characterized by a blood-alcohol concentration of 0.08 or higher), is vital to developing effective alcohol related policies regarding youth.

This semester I had the opportunity to hear Dr. Magdalena Szymanska share her research about binge drinking effects on the brains hypothalamo-pituitary-adrenocortical (HPA) axis, which is important in the response to stress. In preliminary studies Dr. Szymanska showed that rat corticotrophin-releasing hormone (CRH), arginine vasopressin (AVP), and corticosterone (CORT) levels were altered in rats exposed to binge levels of ethanol (the chemical in alcohol that causes intoxication). Her subsequent research showed that dysregulation of theses hormones persists into adulthood (Szymanska 2011). In some of her even more recent research she has produced evidence that binge levels of alcohol consumption during adolescence can cause genetic changes that are passed down to rats children. Since the HPA axis has been shown to be important in the regulation of stress, research like Dr. Szymanska’s is important to help understand how alcohol induced dysregulation of hormones and modification of gene expression effect psychological disorders.

In 2012 Dr. Ryan Vetreno and Dr. Fulton Crews published a study that examined the effects of adolescent alcohol consumption (again in rats) on increased neuroinflammation and cognitive performance. Vetreno and Crews randomly assigned rats to either a test group that received intragastric ethanol or a control group that received intragastric injections of water. Then the effects of alcohol consumption were evaluated using immunohistochemistry and Barnes maze spatial and reverse learning assessment. Immunohistochemistry along with polymerase chain reaction is a biological lab technique used to quantify the amount of expression of a gene. In this study it was used to look at HMGB1, a molecular signal of neuroinflammation. Vetreno and Crews found that alcohol consumption caused increased levels of HMGB1 (aka the “danger signal”) in adult rat prefrontal cortex (the part of the brain that is important for cognitive functions). The Barnes maze was used to assess the correlation between cognitive deficits and increased gene expression of prefrontal cortex “danger signals”. Ventro and Crews found that while the ability of rats to form spatial memories was not impaired, their ability to unlearn and replace the formed spatial memories was impaired (they had impaired reverse learning abilities). This group of experiments helps us to understand how prefrontal cortex biological changes due to alcohol consumption relates to deficits cognitive abilities.

These are just two studies of many that help us understand how molecular and genetic changes in the brain due to adolescent alcohol consumption correlate to different psychological deficits. There is a lot more work that needs to be done to really understand how the adolescent brain is affected by alcohol and how those effects can be reversed. Personally, I hope that research findings like these can be adapted to serve as effective deterrents to keep youth from consuming large amounts of alcohol.

Articles:



Przybycien-Szymanska MM, Mott NN, Paul CR, Gillespie RA, Pak TR (2011) Binge-Pattern Alcohol Exposure during Puberty Induces Long-Term Changesin HPA Axis Reactivity. PLoS ONE 6(4): e18350. doi:10.1371/journal.pone.0018350

Ventro RP, Crews FT (2012) Adolescent Binge Drinking Increases Expression of the Danger Singnal Agonist HMGB1 and Toll-Like Receptors in the Adult Prefrontal Cortex. Neuroscience 226: 475-488.

Friday, December 6, 2013

"Strength does not come from physical capacity. It comes from an indomitable will." -Gandhi

Arthur Kramer, the director at the Beckman Institute for Advanced Science and Technology at the University of Illinois in Urbana-Champaign, came to talk about what the effects of exercising can have on your brain and body. I was very excited to hear Dr. Kramer speak because I heard that the topic was about how exercising can help improve your brain. We've all heard of the stats on what exercising can do, but even I was unsure about the specific effects exercising can have on the brain. I just know the common response, "Exercise is good for you!" but could never scientifically explain why. Dr. Kramer began to explain how exercising, even walking everyday, can have a significant long-term effect on someone's mental health. He continued to go into detail about his studies and data that he's collected. I wish I could explain and share everything I learned from him, but I'm going to focus on when he mentioned the link between exercising and Alzheimer's Disease.


Alzheimer's disease is characterized by plaques and tangles, abnormal clusters of proteins that form in the brain. These proteins are made up of pieces called beta-amyloid. Beta-amyloid is then what form the plaques in the brain of an Alzheimer's patient. These clumps of beta-amyloid are what is thought to block the signaling at synapses between neurons. Dr. Kramer talked about the experiment with mice testing whether or not exercise would have an effect on the production of beta-amyloid. Once the mice were put on a track wheel, the number of beta-amyloid reduced. Even though this was tested on mice, this seems to be a pretty reassuring discovery that exercising can help reduce the chances of forming beta-amyloid clumps, reducing the chances of Alzheimer's disease. Art Kramer spoke of many other experiments that showed how exercising reduced the chances of developing Parkinson's disease or Multiple Sclerosis. His talk was very inspiring and motivating to push people even more to exercise. By knowing the science behind the long-term effects of exercising, I am beyond motivated to get back to a regular work out schedule and also motivating my family and friends to work out. Exercise doesn't necessarily need to be running 6 miles, lifting large weights, or P90X, but can instead start off as walking everyday or swimming some laps a few days a week. Depending on someone's fitness level, the amount of exercise they do can vary and there is nothing wrong with starting off at a comfortable exercise routine. Anyone can work up to achieving a higher fitness level. It is better to start exercising, even if that means starting off small because it's better than doing nothing at all.

Huntington's Just Want to Lay Down

Exercise! Wow the one shot cure

Dr. Kramer’s lecture raved about the benefits of exercise in aging and as a way to help delay and even prevent the onset of mental disorders and cognitive degenerative diseases in some cases. I thought that these finding were amazing and immediately felt the need to get up and get moving, keeping the body healthy to keep the mind well lubricated so to speak. However what really caught my attention was not the benefits that exercise provided but the one exception to this almost perfect treatment. Very briefly Dr. Kramer mentioned that exercise helps virtually everything except for Huntington’s disease. It wasn’t hard to then ask why and what makes Huntington disease so special.

So what is Huntington’s Disease?


            Huntington's disease is caused by a defect on chromosome 4 that causes a part of DNA, called a CAG repeat, to occur many more times than it is supposed to. As individuals with this disease have children the abnormal replicates become increasingly abundant. Normally, this section of DNA is repeated 10 to 28 times but in persons with Huntington's disease, it is repeated 36 to 120 times and with each added replication the chances of developing this disease earlier in live rises. (PubMed 2011) What makes it particularly devastating is the fact that these replicated sequences can seriously mutate and denature proteins and as a result lead to disorders like paranoia, hallucinations, uncontrolled body movements (jerking, twitching and eye spasms) and dementia in some cases.

So how does exercise affect it?

            In a study published in 2010 researchers looked at the effects of exercise on rats with Huntington’s disease, what they found was interesting. They concluded that “exercise impaired motor performance and reduced striatal volume and age of disease onset in a HD mouse model. In addition, total lifespan, progressive weight loss, hyperglycemia, reduced neurogenesis, deficits in immature neuronal morphology; intra-nuclear inclusions, decreased GCL volume and impaired cognitive performance were not changed by exercise.” (Potter et al. 2010) So not only was exercise unable to prevent the onset of HD it actually induced its onset earlier in the rat’s life. A similar study done by Renoir et al. in 2012 looked at the effects of exercise on depressed rats with HD and found similar results, the rats that showed increase activity levels were seen to perform poorly on Morrison’s water maze and also shown increase motor disorders measured by the number of missteps that the rats made.

But why?

I have no idea, it could be a number of things but perhaps the increased metabolism rates of active individuals not only speeds up bodily functions but accelerates abnormal replications of the CAG sequence found in Huntington’s Disease and as a result causes the disease to occur earlier in the organisms life. There isn't a lot of new research that is published yet but I feel in the coming years that this topic might become really hot really fast.   


Work Cited
Board, A.D.A.M. Editorial. "PubMed: Huntington's Disease." Huntington's Disease. U.S. National Library of Medicine, 30 Apr. 2011. Web. 04 Dec. 2013. <http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001775/>.
Potter, Michelle C., Chunyan Yuan, Conwell Ottenritter, Mohamed Mughal, and Henriette Van Praag. "Abstract." National Center for Biotechnology Information. U.S. National Library of Medicine, 07 Dec. 2010. Web. 06 Dec. 2013. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998194/>.


Renoir, Thibault, Terence YC Pang, Michelle S. Zajac, Grace Chan, Xin Du, Leah Leang, Caroline Chevarin, Laurence Lanfumey, and Anthony J. Hannan. "Treatment of Depressive-like Behaviour in Huntington's Disease Mice by Chronic Sertraline and Exercise." Treatment of Depressive-like Behaviour in Huntington's Disease Mice by Chronic Sertraline and Exercise (2012): n. pag. Mar. 2012. Web. 6 Dec. 2013. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372723/>.

Exercise and the Hippocampus

Dr. Art Kramer presented his research on the cognitive effects of exercise on November 30th to a rapt audience, myself included. There are plenty of reasons to exercise: increased cardiovascular endurance, stress reduction, and overall body appearance and tone. But, it can be easy to fall off the exercise bandwagon sometimes. I try to workout a maximum of five days a week; sometimes I only make it to 2 or 3 days, and I sometimes I get too stressed with school and validate skipping the gym entirely. For me, it's easy to rationalize not exercising to strengthen my heart because I'm 21 and don't really need to think about that. School often takes precedence. However, what if exercising and working your body helped with school in the long run?

Dr. Kramer discussed how exercise can improve connectionism and aging, and how exercise can also improve cognitive functioning in children. High-fit children were less distracted by music when they were in the simulated street crossing and had way better decision making skills. These are very clear and apparent reasons to get up and exercise, even when you're stressed! The subject of exercise and the brain is actually what first spurred my fascination with neuroscience a few years ago. I remember reading a paper about how the old adage "The brain cells you're born with are the only ones you've got" was actually false, and how research was found neurogenesis and new cell production in the hippocampi of rats who ran regularly. This really got my attention, and is something that I am interested in researching with adults and depression. Most doctors recommend exercise for depressed patients, but this is definitely an area that could use more exploring in terms of the actual neurological affect of exercise on the brain and why it improves depressive patients functioning.

If exercise improves hippocampal volume and thus aging and emotional coping, everyone should really get the recommended amounts of exercise for their own sake. However, working out and being healthy can be confusing sometimes because there's so many options, and so many conflicting ideas for what kind of exercise is the most beneficial for each person. In a study by Kirk Erickson and colleagues (including Dr. Kramer as well!), the researchers attempted to elucidate exactly this. They compared individuals who either took place in an exercise condition with moderate-intensity aerobic exercise or in a toning and stretching condition. They found that the aerobic exercise increased hippocampal volume by 2% and increased associated BDNF levels (Brain derived neurotrophic factor, a nerve growth factor) (Erickson et al. 2010). Hippocampal shrinkage is associated in aging, so this has huge implications for aging and Alzheimer's prevention!

References:
Erickson, K. et al. (2010). Exercise training increases size of hippocampus and improves memory, PNAS, 108(7), 3017-3022.

Exercise and Alzheimer's

On November 20, 2013, Dr. Art Kramer from the University of Illinois came and spoke about the effects of physical activity on the brain and cognition. He spoke of research done on high and low fit children and an experiment of a stimulated street crossing, similar to Frogger. The high and low fit children did about the same at first, but when they were distracted by music, the high fit children were making better decisions about when to cross.

I found it very interesting that there was a difference between this children and it make me wonder about the effect of exercise in preventing or delaying degenerative diseases such as Alzheimer's. Dr. Kramer touched on it for a minute about how it might be able to set the clock back, but I decided to look further into it. According to the Mayo Clinic, physical exercise is currently the most effective way to prevent Alzheimer's. (Lunde, 2008) There is evidence of this in a study done at the University of Chicago with mice that have been bred to develop the brain plaque that can cause Alzheimer's. Only some of the mice were allowed to exercise and those that were had 50-80% less plaque than the mice that were not allowed to exercise. The exercising mice had less plaque because they produced more of an enzyme that prevents the plaque. (Lunde, 2008)

In conclusion, if you did not have enough of a reason to exercise before, this should get you to the gym very quickly.

Lunde, A. (2008, March 25). Preventing alzheimer's: Exercise still best bet. Retrieved from   
          http://www.mayoclinic.com/health/alzheimers/MY00002

Wednesday, December 4, 2013

Art Kramer: An even better reason to exercise (as if we really needed another)

I attended Art Kramer's talk with two of my close friends. By the time we left the event, we had made a pact to be exercise buddies during the upcoming semester. We'll see how well that plan holds up, but it got me thinking: why was Art Kramer's presentation so much more motivating than the MILLIONS of other reasons that there are to exercise regularly? The fact that exercising is good for us has really never been disputed, unless you're injured nothing but good can come of it. However, we often think of the benefits as being purely aesthetic and physical. Sure, it's great to feel good, look good, and stay physically healthy into old age, all of these are extremely desirable benefits. However, I would argue that, especially as we age, we are much more attached to our mental acuity than to our physical well-being. Physical decline is uncomfortable and inconvenient, mental decline is debilitating. On a certain level we ARE our minds; to lose mental capability is essentially to lose a part of ourselves. People seem to have a much easier time coming to terms with the physical losses of aging. Can't play a sport that you used to enjoy anymore? It's a bummer, but after all I am getting older. Can't find your car keys or remember the name of a distant acquaintance? That's it, it's over, the dementia is here. So, Kramer's studies give us a special sense of hope. Something that is usually never associated with mental preservation has suddenly become an option, even when mental faculties seem to be on the way out. The study that Kramer presented about the effect of exercise in patients that already had Alzheimer's, MS and Parkinson's was probably the most impressive to me. It's easy to believe that exercise could have a positive effect in people who still have a healthy brain, but when it can improve or help lessen the effect on already diseased brains you know that it is rather powerful. What did I take away from this talk? It's never too late to improve your mind and exercise really does help everything.